The inhibition of protein-lysine 6-oxidase by various lathyrogens. Evidence for two different mechanisms.
نویسندگان
چکیده
Lathyrogens decrease collagen and elastin cross-linking by inhibiting lysine oxidase. The lathyrogens isoniazid and semicarbazide decrease liver pyridoxal phosphate and are teratogenic; all their effects are reversed by pyridoxal. beta-Aminopropionitrile, another lathyrogen, does not affect liver pyridoxal phosphate, and its lathyrogenic and teratogenic effects are not reversed by pyridoxal. Time courses of these effects differ greatly, suggesting enzyme inhibition by different mechanisms.
منابع مشابه
مطالعه تغییرات متابولیت‌های سازگاری و فعالیت آنزیم‌های آنتی اکسیدانت ارقام مختلف گندم تحت تنش رطوبتی
To study the effects of water stress on compatibility metabolites and the antioxidant enzyme activities of wheat variety trial a factorial experiment was conducted in a completely randomized design in 1393. The experiment consisted of three levels of stress (85, 60 and 35% of field capacity) and five varieties of wheat (Orom, Zarea, Mihan, ZSZOBKAYKA, JS3l7G217,) Analysis of variance showed, Pr...
متن کاملتاثیر کلرید کادمیوم و جیوه بر میزان قند محلول، پروتئین کل، اسید آمینه‌های پرولین، لیزین، متیونین و برخی آنزیم‌ها در دو رقم گندم نان (Triticum aestivum L.)
Heavy metals are a major environmental problem and have caused serious concerns because of characteristics of carcinogenesis, non-degradability and biological accumulation. Major part of this material is absorbed by plants and leads to inactivation of some enzyme, decreased protein production and disrupting variety of reactions and many cellular functions and growth and development cessation. T...
متن کاملA Kinetic Comparison on the Inhibition of Adenosine Deaminase by Purine Drugs
The effects of allopurinol, acyclovir and theophylline on the activity of adenosine deaminase (ADA) were studied in 50 mM sodium phosphate buffer pH 7.5 at 27°C, using a UV– Vis spectrophotometer. Adenosine deaminase is inhibited by these ligands, via different types of inhibition. Allopurinol, as a transition state analog of xanthine oxidase, and acyclovir competitively inhibit the catalytic a...
متن کاملA Kinetic Comparison on the Inhibition of Adenosine Deaminase by Purine Drugs
The effects of allopurinol, acyclovir and theophylline on the activity of adenosine deaminase (ADA) were studied in 50 mM sodium phosphate buffer pH 7.5 at 27°C, using a UV– Vis spectrophotometer. Adenosine deaminase is inhibited by these ligands, via different types of inhibition. Allopurinol, as a transition state analog of xanthine oxidase, and acyclovir competitively inhibit the catalytic a...
متن کاملاثر منبع نیتروژن بر برخی صفات فیزیولوژیکی و بیوشیمیایی لوبیا در شرایط تنش کم‌آبی
Nitrogen has an important role for supplying carbon skeletons which needs for producing compatible solutes and stress tolerance enzymes. Water deficit affects nitrogen fixation in legums. So we studied the effect of various nitrogen sources on physiological, and biochemical features of bean under water stress. This experiment was conducted as factorial based on completely randomized design with...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Biochemical journal
دوره 232 1 شماره
صفحات -
تاریخ انتشار 1985